Shahzad Tahmasbi; Ahmad Farokhi; Naser Naghdi; Fazlolah Bagherzade; Anoushirvan Kazemnejad; Mehdi Shahbazi
Volume 1, Issue 2 , October 2009, , Pages 21-46
Abstract
The purpose of this study was to evaluate the effect of two regimes during rats' gestation and lactation on learning, memory and motor function of their offspring. For this purpose, female rats (Albino-Wistar) were obtained from Pasteur Institute, Iran. After mating, 12 pregnant rats were divided into ...
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The purpose of this study was to evaluate the effect of two regimes during rats' gestation and lactation on learning, memory and motor function of their offspring. For this purpose, female rats (Albino-Wistar) were obtained from Pasteur Institute, Iran. After mating, 12 pregnant rats were divided into three groups and they had their special regimes during their last week of pregnancy as well as their lactation. Control group used a standard diet, the zinc deficient (ZnD) group a diet deficient in zinc and the zinc supplement (ZnS) group a standard diet and enhanced zinc (10ppm) in their drinking water. 12 male offspring in each group were selected as the statistical sample and they were tested for learning and memory in MWM on their 56th natal day (ND) and were tested for motor activity in open-field on their 66th natal day. One-way ANOVA, post hoc Tukey test and repeated measures ANOVA were used to analyze the data (P
Mehdi Shahbazi; Mahmud Sheikh; Naser Naghdi; A Farokhi; Anoushirvan Kazem nejad; Shazad Tahmasbi
Volume 1, Issue 1 , July 2009, , Pages 5-25
Abstract
The purpose of this research was to determine the effect of two kinds of diet (zinc deficiency and iron deficiency) on some anthropometrical indexes (body weight and crown-rump length), brain growth and motor function in young rats. Adult male and female albino wistar rats were obtained from the breeding ...
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The purpose of this research was to determine the effect of two kinds of diet (zinc deficiency and iron deficiency) on some anthropometrical indexes (body weight and crown-rump length), brain growth and motor function in young rats. Adult male and female albino wistar rats were obtained from the breeding colony of Pasteur Institute, Iran. The female albino rats were mated with normal male rats. After delivery, 40 male rats per group were selected. In order to measure physical and brain growth a special caliper (0.01 mm) and electronic balances (0.0001 g) were used. The instruments for motor function evaluation were Morris Water Maze and Open Field Arena. The data were analyzed by one-way ANOVA and post-hoc analyses were carried out by Tukey’s test (P?0.05). There were significant effects of iron and zinc deficiency on serum iron and zinc level. The results showed that serum iron and zinc concentration after the diet (contrary to the condition before diet) in ZnD and FeD groups were significant. There was a significant difference in some anthropometrical indexes (body weight, crown-rump length) and motor function between ZnD, FeD and control groups but there was no significant difference in brain weight between ZnD, FeD and control groups. The results of this study suggest that sufficient zinc and iron affect motor function as well as physical and brain growth.
