Atena Yazdanshenas; Maghsoud Peeri; Mohammad ali Azarbayejani
Abstract
The aim of this study was to examine the positive effects of forced andvoluntary exercises as a non-pharmacological factor on modified behaviorsdue to stress of separation from mother. In the present study, 48 male babyrats were selected and separated from their mothers from day 2 to 14 for 180minutes. ...
Read More
The aim of this study was to examine the positive effects of forced andvoluntary exercises as a non-pharmacological factor on modified behaviorsdue to stress of separation from mother. In the present study, 48 male babyrats were selected and separated from their mothers from day 2 to 14 for 180minutes. On the 21st day, these rats were randomly divided into 4 groups.The groups included maternal stress, control, treadmill, running wheel (RW).The first group experienced stress of separation from their mothers from day2 to 14 and the control group was kept from the beginning with theirmothers. The exercise groups also began to exercise since their 21st birthday. Then, the groups conducted behavioral anxiety and rodent depressiontests including EPM, Splash, FST, and Open Field. The obtained data werestatistically analyzed by t and ANOVA methods at a significance level(P<0.05). Behavioral tests showed that the stress of separation from themother caused depression behaviors. On the other hand, voluntary exercisecaused antidepressant effects compared with the stress group while nosignificant changes were observed between the effect of forced exercise andthe stress group. The results showed that exercise, especially voluntaryexercise, reduces stress during adolescence, and reduces depression andanxiety behaviors in adulthood.
Mohammad Ali Salianeh; Rasoul Hemayattalab; Mahmoud Sheikh; Naser Naghdi
Abstract
The aim of this study was to investigate the effect of forced physical exercise with moderate intensity on Alzheimer-induced amnesia in adult male rats. 48 male Wistar- Albino rats were randomly selected and assigned to 6 groups (n=8 per group): control, placebo (saline), drug-exercise, saline-exercise, ...
Read More
The aim of this study was to investigate the effect of forced physical exercise with moderate intensity on Alzheimer-induced amnesia in adult male rats. 48 male Wistar- Albino rats were randomly selected and assigned to 6 groups (n=8 per group): control, placebo (saline), drug-exercise, saline-exercise, exercise and exercise-drug. In this study, Dicyclomine (16 mg/kg) was used to induce Alzheimer-like amnesia and moderate exercise (60 minutes per day × 30 days). The rats were trained and tested using Morris water maze. The findings showed that the group receiving Dicyclomine increased delay in reaching the platform in acquisition (P=0.044) and recall (P=0.031) compared with exercise, control and saline groups. But there were no significant differences between exercise and exercise-saline groups compared with exercise-Dicyclomine group. Also, a significant difference (delay in reaching the platform) was observed between Dicyclomine-exercise, saline-exercise compared with Dicyclomine in acquisition (P=0.005) and recall (P=0.002). In conclusion, this study showed that memory and learning in the acquisition and recall phases were destroyed by Dicyclomine and 30 sessions of moderate-intensity running (forced) could prevent memory corruption.
