Document Type : Research Paper


1 Ph.D Student, University of Tehran

2 Associate Professor, Faculty of Physical Education, University of Tehran

3 Associate Professor at Tehran University


Background and Aim: In recent studies of balance and instability, a condition has been reported as a common motor disorder in Parkinson's patients, leading to frequent falls, decreased quality of life and mortality in these patients. On the other hand, evidence has shown that exercise is effective in treating motor and cognitive symptoms of neurodegenerative patients.

Method: 24 male Wistar rats were randomly divided into three groups: healthy control, Parkinson's control, and Parkinson's training. The animals in the training group were placed on a treadmill for 4 weeks. At the end of the course, motor disturbances (balance and motor behavior) were evaluated using Rotarod and Open-Field tests, and biochemical factors were assessed by ELISA method.

Results: Data analysis and analysis using one-way ANOVA and Tukey's post hoc test at a significant level (p