Ali Seghatoleslami; Mahmood Shaikh; Naser Naghdi; Elahe Arab Ameri; Nabiollah Numvar Asl
Abstract
It is important for people to improve cognitive and motor performance. The purpouse of this study was to investigate the effect of running on treadmill in spatial memory and learning and motor performance. 24 Albino-Wistar healthy male rats were randomly divided into control and activity groups. Activity ...
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It is important for people to improve cognitive and motor performance. The purpouse of this study was to investigate the effect of running on treadmill in spatial memory and learning and motor performance. 24 Albino-Wistar healthy male rats were randomly divided into control and activity groups. Activity group ran 7 days on treadmill (speed 22m/min 30 minutes a day). After the end of activity period, Morris Water Maze and open-field tests were done to respectively assess spatial learning and motor performance. It was used latency time, and distance moved to find platform to assess spatial learning, and distance moved, mobility duration, and movement speed to assess motor activity. It was used SEM±M and analyze variance (2groups*3days) and independent-t tests to analyze data.Results indicated that In spatial learning, activity group was significantly better in acquisition (distance moved F2,44=6/578 p=0/003 and latency time F2,44=10/550, p=0/000 ), probe (time spend in target quarter t22=2/534 , p=0/019), and retrieval tests (distance moved t22=2/651, p-0/015) than control group. In motor activity there was no significant difference between two groups.The results of this study show that the forced running of rats on treadmill for a week can improve learning and memory.
Nasour Ahmadi; Mohammadali Aslankhani; Naser Naghdi
Abstract
Aging has negative effects on motor and cognitive functions, so it is essential to identify appropriate strategies to prevent the decrease of motor and cognitive functions. The aim of this research was to investigate the effect of vitamin E supplement on motor activity and spatial learning in aged rats. ...
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Aging has negative effects on motor and cognitive functions, so it is essential to identify appropriate strategies to prevent the decrease of motor and cognitive functions. The aim of this research was to investigate the effect of vitamin E supplement on motor activity and spatial learning in aged rats. 36 male Albino – Wistar aged rats were assigned to three groups of control, vitamin E and sham. E group received daily 100 mg (50 IU) of vitamin E per kg of body weight with 0.5 ml sesame oil via gavage during 8 weeks. Sham group received daily 0.5 ml sesame oil, but control group did not receive any treatment. After the end of the protocol, open – field and Morris water maze tests were used to respectively assess motor functions and spatial learning. Distance moved and movement speed was used to assess motor function and latency and distance moved to the find platform was used to assess spatial learning. Results showed that in motor function, there was no statistically significant difference among groups in distance moved and movement speed factors (P>0.05). In addition, there was no statistically significant difference among groups in all factors of spatial learning and memory (P>0.05). The results showed that vitamin E did not significantly influence motor and cognitive functions of aged rats. Vitamin E supplement appears not to be efficient in the aging period when antioxidant damages caused irreversible memory destruction.
