sepide jalali; Hassan Mohammadzade; jalal Dehghanizade
Abstract
Introduction: Menopause is the beginning of a new era in a woman's life. This period, like all other stages of life, has positive and negative aspects. The present study aimed to investigate the effectiveness of Pilates exercises on serum BDNF level, balance, and quality of life in menopausal and non-menopausal ...
Read More
Introduction: Menopause is the beginning of a new era in a woman's life. This period, like all other stages of life, has positive and negative aspects. The present study aimed to investigate the effectiveness of Pilates exercises on serum BDNF level, balance, and quality of life in menopausal and non-menopausal women.Methods: The current study was a quasi-experimental research with a pre-test and post-test design that included two experimental and two control groups. The sample consisted of 60 menopausal and non-menopausal women (age 45.77±1.77 years) who were voluntarily selected and randomly assigned into four groups of 15 people. Fasting blood was drawn from all the participants 48 hours before the start of training and after the end of the training period. Then both experimental groups performed Pilates exercises for 12 weeks, three sessions per week and each session lasted 60 minutes. Also, the participants similarly performed the Y dynamic balance test and completed the World Health Organization Quality of Life (WHOQOL) questionnaire in pre-test and post-test.Results: The results of Mixed ANOVA showed a significant difference between the pre-test and the post-test of menopausal and non-menopausal women in relevant variables, so it can be said that probably 91%, 76%, and 94% of the changes in serum BDNF levels, balance and quality of life of menopausal and non-menopausal women are influenced by Pilates exercises. However, no significant effect was observed in the relevant variables of control groups (P≤0.05).Conclusion: Pilates exercises can be an effective strategy to improve serum BDNF levels, balance, and quality of life in menopausal and non-menopausal women.
Tahmineh Karbalaee Sadeghi; Morteza Taheri; Khadijeh Irandoust
Abstract
Introduction: Colon cancer or colorectal cancer is the growth of cancerous masses in the colon. According to research evidence, the use of antioxidants and regular exercise are the best ways to prevent and treat many diseases. This study aimed to investigate the effect of eight weeks of intermittent ...
Read More
Introduction: Colon cancer or colorectal cancer is the growth of cancerous masses in the colon. According to research evidence, the use of antioxidants and regular exercise are the best ways to prevent and treat many diseases. This study aimed to investigate the effect of eight weeks of intermittent exercise and Quercetin consumption on the brain-derived neurogenic factor (BDNF) and cyclic-adenosine monophosphate responsive element-binding protein (CREB) in the brain hippocampus of rats with colon cancer which has many influences on cognitive functions.Methods: The subjects of this study included 50 male Wistar rats (weight: 250±30 grams, age: 12 weeks) which were homogenized by weight and were randomly divided into five Healthy Control, Cancer Control, Cancer + Quercetin supplement, Cancer + Intermittent exercise, Cancer + Quercetin supplement + Intermittent exercise groups (10 rats in each group). BDNF and CREB measurements were performed in the rats’ hippocampus according to the ELISA standards and method. SPSS software was used for data analysis.Results: The results showed that eight weeks of intermittent exercises had a significant effect on the mean score of BDNF (p = 0.047) and CREB (p = 0.032) in rats’ hippocampus with colon cancer. Eight weeks of Quercetin supplementation had no significant effect on the mean BDNF score (p = 0.792) and the mean CREB score (p = 0.363) in rats’ hippocampus with colon cancer Conclusion: In general, the findings showed that intermittent exercise and Quercetin supplementation improve BDNF and CREB in the hippocampus of rats with colon cancer.
Abolfazl Shayan; Hamideh Iranmanesh; Mehdi Yazdanpanah; Mohammad Ali Dowlati
Abstract
Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that is highly expressed in the structures of the central nervous system and affects synaptic plasticity and the acquisition of motor and cognitive skills. This is while val66met polymorphism disrupts the amount and expression of BDNF. ...
Read More
Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that is highly expressed in the structures of the central nervous system and affects synaptic plasticity and the acquisition of motor and cognitive skills. This is while val66met polymorphism disrupts the amount and expression of BDNF. So, in the present study, the researchers aimed to investigate the effect of polymorphism on the learning of a motor sequence task.Methods: One hundred students from Kashan University (mean age 21.60 ± 2.60) participated in the study. After extraction of Genomic DNA, implementation of the polymerase chain reaction (PCR) by forwarding primer 5-ACTCTGGAGAGCGTGAAT-3 and reverse primer 5-ATACTGTCACACACGCTG-3, analyzing PCR by 1.5 percent Electrophoresis Gel, and eventually, DNA sequencing by Sequencing Analyzer, 46 participants were identified without the polymorphism and 54 participants were identified met-carriers (affected by the polymorphism). Then, retention, visual-spatial transfer, and motor transfer of the motor sequence task were tested by the Dynamic Arm Movement Task.Results: Results showed people without the polymorphism progressed faster than met-carriers and also performed the task better on the retention test (P=0/001). They were also better than met-carriers in the motor transfer test (P=0/001), but there was no significant difference between the two groups in the visual-spatial transfer test (P=0/176).Conclusion: It seems that met-carriers, in any way, go through the early stages of motor learning, but due to possible problems caused by the polymorphism, they are weak in completing the learning process.
Amir Dana; Zynalabedin Fallah; Jalil Moradi; Akbar Ghalavand
Abstract
Introduction and aims: Brain-Derived Neurotrophic Factor (BDNF) as one of the factors associated with neuromuscular performance and cognitive function is reduced with increasing age. The objective of the present study was to investigate the effects of aerobic and cognitive training on the dynamic balance, ...
Read More
Introduction and aims: Brain-Derived Neurotrophic Factor (BDNF) as one of the factors associated with neuromuscular performance and cognitive function is reduced with increasing age. The objective of the present study was to investigate the effects of aerobic and cognitive training on the dynamic balance, attention and serum BDNF levels in elderly men. Methods: In a quasi-experimental study, 60 healthy elderly men were selected through the purposeful sampling and were randomly divided into 4 groups including aerobic training, cognitive training, combinational training (cognitive aerobics) (cognitive training), and control. Training was performed during eight weeks at three sessions per week. T-test and one way ANOVA were used to analyze the data (P≤0.05). Results: at the end of the period, a significant increase was observed in BDNF serum in the intervention group compared to the control group (P ≥0.001). Also, there was a significant increase in the ratio of the correct response on the target and non-target stimuli. In addition, a significant decrease was observed in commission errors and omission errors, and reaction time in intervention groups compared to control groups (P<0.05). It can be added that the significant improvement was observed in dynamic balance in aerobic and combination groups compared to the control (P<0.001) and cognitive training (P<0.05). Conclusion: Cognitive and aerobic training lead to improving the attention and balance performance in the elderly with increasing BDNF, and it is better to use a combination of physical and cognitive training for the elderly.
