Sara Soori; Fazlolah Bagherzadeh; Rasoul Hemayat talab
Abstract
Introduction: In recent studies, balance and postural instability have been reported as a common motor disorder in Parkinson's patients, which leads to frequent falls, decreased quality of life, and mortality in these patients. On the other hand, evidence has shown that training is effective in treating ...
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Introduction: In recent studies, balance and postural instability have been reported as a common motor disorder in Parkinson's patients, which leads to frequent falls, decreased quality of life, and mortality in these patients. On the other hand, evidence has shown that training is effective in treating motor and cognitive symptoms of neurodegenerative patients.Methods: For this purpose, 24 male Wistar rats were randomly divided into three groups of eight rats including Healthy Control, Parkinson’s Control, and Parkinson’s Training. The animals in the training group were placed on a treadmill for four weeks. At the end of the course, motor disorders (balance and motor behavior) were evaluated using Rotarod and Open-Field tests, and biochemical factors were assessed by ELISA method. Data analysis was done using one-way ANOVA and Tukey's post hoc test at a significant level of P<0.05, via SPSS version 19 software.Results: The results showed that although the Parkinson's group without training was significantly lower in terms of motor performance than the other groups (P<0.05), four weeks of moderate-intensity aerobic training increased the balance (P<0.05), and improved the motor disorders in Parkinson's rats (P<0.05). Also, training significantly increased the amount of serotonin (P<0.05), and tyrosine hydroxylase (P<0.05).Conclusion: In general, the findings of this study showed that moderate-intensity aerobic training can reduce the biochemical and motor disorders induced by 6-hydroxydopamine injections in rats’ models of Parkinson's disease.
Zahra Soori; Ali Heyrani; Rahman Souri
Abstract
The role of the training is to improve the symptoms of Parkinson's disease. The purpose of this study was to compare the effects of exercise intensity on learning, spatial memory and anxiety behaviors in rat with impair . In this study, 24 male rats were randomly divided into 5 healthy control groups, ...
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The role of the training is to improve the symptoms of Parkinson's disease. The purpose of this study was to compare the effects of exercise intensity on learning, spatial memory and anxiety behaviors in rat with impair . In this study, 24 male rats were randomly divided into 5 healthy control groups, Parkinson's control, Parkinson's (low, moderate, and high intensity) exercises. The creation of the Parkinson's Model was injected intra-brain-6-hydroxydopamine. To assess learning and spatial memory, Morris water maze test and Counting Counting were used as an indicator of anxiety behavior. Data analysis was done by one-way ANOVA at a significant level (P <0.05). Injection of 6-hydroxydopamine increased the duration of the platform and destroyed spatial memory (P <0.05), Although all three types of space memory training decreased significantly in Parkinson's rats significantly (P <0.05), high intensity exercise showed the greatest effect on learning and spatial memory (0.05). (P <0.05), there was a significant difference between the high and low intensity training groups (P <0.05). This difference was not significant between the moderate and low intensity groups in most of the variables (P <0.05). Different intensities, especially high intensity, improve the parameters of spatial memory
